Santana is a flexible number of musicians accompanying Carlos Santana since the late 1960s. Just like Santana himself, the band is known for helping make Latin rock famous in the rest of the world.

The band was formed in 1966 in San Francisco. The first members were Carlos Santana (lead guitar), Tom Frazier (guitar), Mike Carabello (percussion), Rod Harper (drums), Gus Rodriguez (bass) and Gregg Rolie (keyboard, vocal). In the following years the members of the group changed frequently for a number of reasons, and from 1971 to 1972 there was a brief separation between the group and Santana.

Santana himself rarely sings in his songs despite being the leader of the band and recent hits have been frequently accompanied by a guest singer, rather than the members of the band.

In 1998, the group was inducted into the Rock & Roll Hall of Fame, with Carlos Santana, Jose Chepito Areas, David Brown, Mike Carabello, Gregg Rolie and Michael Shrieve being honored.